The new research paper shows the growing evidence that the lives attenuated vaccines can actuate specific immune cells to train leukocytes (the white blood cells of the immune system) to ascend a more effective shield against unrelated infections.
The scientist emphasizes that this live attenuated MMR (measles, mumps, and rubella) vaccine concept is not recommended to be used for the treatment of COVID-19. Instead, the MMR vaccine can be used as an immune preventive measure for treating the severe inflammatory symptoms of the virus.
The new paper published in mBio, an open-access American Society for Microbiology scientific journal, indicates that live attenuated vaccines like MMR (measles, mumps, and rubella) virus might restrict severe lung inflammation and sepsis associated with COVID-19 infection.
A live attenuated vaccine is obtained from a disease-causing pathogen that has been weakened in the laboratory so that it does not cause severe illness when a person is vaccinated with the MMR vaccine.
The scientist used a live attenuated fungal strain. In the lab, they have also demonstrated the MMR vaccination with its trained innate shielding against sepsis (blood poisoning) produced by a combination of disease-causing bacteria and fungi.
The authors of the study have proposed that shielding is produced by cells called MDSCs (myeloid-derived suppressor cell). The authors stressed on the point that this live attenuated MMR vaccine concept is not suggested for the treatment of COVID-19. However, the vaccines will help in preventing immunity against the inflammatory symptoms of Covid-19.
The new research was conducted by New Orleans-based LSU Health’s Paul Fidel Jr and New Orleans-based Tulane University School of Medicine’s Mairi Noverr.
In a statement, Dr. Fidel said that the use of childhood live attenuated vaccines like MMR would give adults the induce bystander cells that could reduce or dampen severe complications associated with COVID-19 infection to a low risk – high reward shielding measure during a difficult time of the novel coronavirus outbreak.
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