A study done on infected human tissue performed at Jerusalem-based Hebrew University (HU) academic noted that fenofibrate, the most popular widely used anti-cholesterol drug, could decrease the danger-level of coronavirus to just a common cold.
In combined research with New York-based Mount Sinai Medical Center's Benjamin R. tenOever and the HU's director of the Grass Center for Bioengineering, Professor Yaakov Nahmias together found that the novel coronavirus is dangerous due to its lipids formation deposited in the lungs which fenofibrate could help in undoing the damage efficiently.
In a press release by HU, Yaakov Nahmias mentioned that if our research is carried out by clinical studies, this course of treatment could effectively downgrade the novel pandemic's severity into nothing adverse than a common cold.
The two scientists focused on the method in which SARS-CoV-2 modifies patients' lungs to reproduce itself. Both found that the virus prohibits the routine burning of carbohydrates. In turn, a large portion of fat gathers inside lung cells, a necessary condition the virus requires in order to reproduce.
The new understanding of SARS-CoV-2 might aid in describing why high cholesterol levels and sugar patients are usually at a particularly high risk of developing COVID-19, Benjamin R. tenOever, and Yaakov Nahmias added.
Yaakov Nahmias further explained that viruses are parasites that lack the capability to recreate on their own, so it takes over the hold of our cells to help finish that task. By understanding the behavioral control of SARS-CoV-2 in our metabolism, we could combat the control from the virus and relieve it of the very resources it needs to sustain itself.
Coming to a conclusion, both the researchers started screening FDA-approved medications that impede the virus' reproducing ability. The cholesterol-lowering drug fenofibrate, which is available under the brand name Tricor, has shown highly promising results during their lab studies.
By permitting lung cells to burn more fats, fenofibrate break down the virus's grip over the cells and curbs SARS-CoV-2's ability to reproduce. The researchers claim that within just 5 days of treatment, the virus nearly wholly disappeared.
Yaakov Nahmias quoted with this second-wave infection spiking in countries across the globe. Our newest findings could not come at a better timing than this. He added that global cooperation might offer a cure.
The research collaboration between the tenOever and Nahmias labs exhibits the power of acquiring a multi-disciplinary approach to study SARS-CoV-2. Besides, our research could genuinely make a noteworthy difference in curbing the global burden of COVID-19, Benjamin R. tenOever added.
The university's press release said currently, there are several international efforts under pipeline to develop a novel coronavirus vaccine. The research also suggests that vaccines might only protect patients for a few months.
Thus, blocking the virus's functional ability instead of neutralizing its ability to strike in the first place, might turn to be the key to turning the tables on COVID-19.
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